IDF sources suggested that the incident Wednesday might not be connected to Gaza rocket fire nor to any of the incidents around Jenin and Nablus.
The IDF is on high alert for "revenge" terror attacks following a failed rocket launch and continued violence in the West Bank.
Sirens sounded on Sunday evening in the areas of Sderot, Sapir College, Gevim, Ivim, Nir Am and Or Haner.
Residents of Psagot warned to stay inside until further warning after possible infiltration.
Rocket alerts were activated in the Zikim settlement area, Kibbutz Carmia and in the city of Ashkelon.
The missile strike comes after Israel's new National Security Minister Itamar Ben-Gvir visited Temple Mount for the first time as a minister.