Two people were killed in a car explosion on Highway 200 near Ramle on Wednesday, according to Israeli media.
The incident has been declared criminal, and the police have opened an investigation into the situation.
The incident occurred in the Neot Shamir neighborhood in the west of the city.
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Police engineers and forensics officers are combing the area for evidence.
Firefighters and Magen David Adom arrived on the scene after a loud explosion was heard in the area around 5 p.m.
Paramedics were unable to immediately access the victims due to the intense fire blazing.
Firefighters extinguished a burning vehicle after which they pulled two people from the car; both were declared dead at the scene.
Medical authorities are still unsure of the identities of the two people killed in the blast.
Recurring crime issues
This is the third such incident in the past few months, in September four people were murdered in an explosion, including a baby, as well as eight wounded.
A week before that, another car bomb killed Mahmoud Abu Ganem in the south of the city near a kindergarten and yeshiva.
Ramle residents told Maariv of their frustration with the police and, in particular, National Security Minister Itamar Ben-Gvir.
"The police will come out with slogans yet again, Ben-Gvir will continue to speak in the Foreign Affairs and Security Committee, and at the end of the day, we, the residents of Ramle, live in fear."
"Such an event, which is a criminal attack in every sense of the word, as the police have already noted, can exact a price on innocent victims. It's not in a specific place or in a specific neighborhood. Crime is rampant throughout the city, everywhere. [People are] afraid to walk the city's streets."