We are nearing the endgame leading to an attack on Iran's nuclear program - or to serious new nuclear negotiations.
Tehran has so far rebuffed Trump's warning to make a deal or face military consequences.
The report comes amid contact between the Islamic Republic and the US over reported efforts to reach a nuclear deal.
Parliament Speaker Mohammad Qalibaf: "If the Americans attack the sanctity of Iran, the entire region will blow up like a spark in an ammunition dump."
Araghchi said that Iran was not opposed to talks out of "stubbornness" but rather as a result of history and experience.
Either Tehran will reach a deal with the US and the E-3 in the next two to three months, or it will face global sanctions and possibly an Israeli air force strike.
In a meeting with senior Iranian officials, Khamenei said the aim of Washington's offer for negotiations was to "impose their own expectations," Iranian state media reported.
Trump said on Friday that something will happen with Iran very soon, adding that he hopes it's a peace deal that blocks the rival from obtaining a nuclear weapon.
"Iran's position regarding nuclear talks is clear and we will not negotiate under pressure and sanctions," Araghchi said.
Behind the Lines | With Iran's proxies weakened and its air defenses damaged, the time is ripe for Israel to act against Tehran's nuclear program.