Israel has taken a substantial bite out of Tehran's nuclear program, but it is far from down for the count.
The jets struck the site, containing Surface-to-Surface Missiles and Cruise Missiles, after receiving guidance from the Intelligence Directorate.
Defrin "could not disclose" whether Khamenei is one of Israel's strike targets when asked by a reporter.
Ali Shamkhani, top adviser to Iranian Supreme Leader Ali Khamenei, was killed in Israeli strikes on a "sensitive military center" in western Iran, local media said.
Despite claims from Iranian officials, Netanyahu said that Israel had caused "real damage" to Iran's nuclear program.
Officials admitted they were worried Iranian civilians would riot should energy or water infrastructure be targeted.
Russia is prepared to continue to work to resolve issues surrounding Iran's nuclear programme, the Russian Foreign Ministry said in a statement.
While Iran moved to replace many key officers, it is not clear who will replace some of the others who were reported killed in Israel’s strikes.
The IDF also released video documentation of the strike alongside its statement.
According to military officials, the pace of Israeli air operations as far as Tehran is expected to accelerate.